Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice.

ABSTRACT: Exposure to ambient air particulate matter (PM_2.5) is well established as a risk factor for cardiovascular and pulmonary disease. Both epidemiologic and controlled exposure studies in humans and animals have demonstrated an association between air pollution exposure and metabolic disorders such as diabetes. Given the central role of the liver in peripheral glucose homeostasis, we exposed mice to filtered air or PM_2.5 for 16 weeks and examined its effect on hepatic metabolic pathways using stable isotope resolved metabolomics (SIRM) following a bolus of ¹³C₆-glucose. Livers were analyzed for the incorporation of ¹³C into different metabolic pools by IC-FTMS or GC-MS. The relative abundance of ¹³C-glycolytic intermediates was

SUBMITTER: Reyes-Caballero H 

PROVIDER: S-EPMC6874681 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature