Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin.

ABSTRACT:

Introduction

Three cerebrospinal fluid (CSF) markers of neurodegeneration (N) (neurofilament light [NfL], total-tau [T-tau], and neurogranin [Ng]) have been proposed under the AT(N) scheme of the National Institute on Aging-Alzheimer's Association Research Framework.

Methods

We examined, in a community-based population (N = 777, aged 50-95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T-tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in-house enzyme-linked immunosorbent assays.

Results

Multiple variables were differentially associated with CSF NfL and T-tau levels, but not Ng. Most ass

SUBMITTER: Mielke MM 

PROVIDER: S-EPMC6874755 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature