The Dilemma of TP53 Codon 72 Polymorphism (rs1042522) and Breast Cancer Risk: A Case-Control Study and Meta-Analysis in The Iranian Population.

ABSTRACT:

Objective

Mutations of TP53 as a tumor suppressor gene are frequently observed in different types of cancer. A codon 72 polymorphism located on exon 4 with two alleles encoding either Proline (CCC) or Arginine (CGC) has been indicated as a common variation in association with cancers. Controversial results have been reported regarding the association of allelic polymorphism of codon 72 of TP53 gene and breast cancer risk in Iranian patients. Therefore, a case-control study was designed. A meta-analysis was also carried out to provide evidence of association between this variation and breast cancer in Iran, based on all available published data.

Materials and methods

In this case-control study, blood sample of 622 participants, including 308 breast cancer cases

SUBMITTER: Afzaljavan F 

PROVIDER: S-EPMC6874791 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature