Two functional variants at 6p21.1 were associated with lean mass.

ABSTRACT:

Background

Low lean body mass is the most important predictor of sarcopenia with strong genetic background. The aim of this study was to uncover genetic factors underlying lean mass development.

Materials and methods

We performed a genome-wide association study (GWAS) of fat-adjusted leg lean mass in the Framingham Heart Study (FHS, N = 6587), and replicated in the Women's Health Initiative-African American sub-sample (WHI-AA, N = 847) and the Kansas City Osteoporosis Study (KCOS, N = 2219). We also cross-validated significant variants in the publicly available body mass index (BMI) summary results (N ~ 700,000). We then performed a series of functional investigations on the identified variants.

Results

Four correlated SNPs at 6p21.1 were identified at the genome-wide

SUBMITTER: Pei YF 

PROVIDER: S-EPMC6874818 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature