In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition.

ABSTRACT: Silica nanoparticles (SiO₂ NPs) have potential utility in controlled release. Despite significant research in this area, there is a gap in the understanding of the correlation between SiO₂ NP physicochemical properties on the one hand and their degradation in solutions, in cells, and in vivo on the other. Here, we fabricated SiO₂ NPs with variations in size, porosity, density, and composition: 100 nm Stöber, 100 and 500 nm mesoporous, 100 nm disulfide-based mesoporous, and 100 nm disulfide-based hollow mesoporous. Degradation profiles over 28 days were investigated in simulated biological fluids and deionized water. Results show Meso 100, and 500 nanoparticles degraded faster at higher pH values. Results from macrophages indicate Meso 100 nanoparticles show

SUBMITTER: Hadipour Moghaddam SP 

PROVIDER: S-EPMC6874921 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature