TMS reveals inhibitory extrastriate cortico-cortical feedback modulation of V1 activity in humans.

ABSTRACT: The interaction between the primary visual cortex (V1) and extrastriate visual areas provides the first building blocks in our perception of the world. V2, in particular, seems to play a crucial role in shaping contextual modulation information through feedback projections to V1. However, whether this feedback is inhibitory or excitatory is still unclear. In order to test the nature of V2 feedback to V1, we used neuronavigation-guided offline inhibitory transcranial magnetic stimulation (TMS) on V2 before testing participants on collinear facilitation, a contrast detection task with lateral masking. This contextual modulation task is thought to rely on horizontal connections in V1 and possibly extrastriate feedback. Results showed that when inhibitory TMS was delivered over V2, contrast th

SUBMITTER: Maniglia M 

PROVIDER: S-EPMC6875154 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature