Cerebellar neural markers of susceptibility to social isolation and positive affective processing.

ABSTRACT: Chronic loneliness predicts mood disturbances and onset of major depressive disorder. However, little research has examined the neural correlates of individual difference in susceptibility to perceiving loneliness. In addition, the role of cerebellum, which is heavily implicated in social, cognitive and affective processes, in loneliness is unclear. We studied 99 healthy individuals divided into susceptible, concordant and robust groups depending on whether the participant's loneliness level was greater, comparable or less than her/his objective social isolation level. The cerebellar gray matter structure, functional activity and connectivity patterns during performing an emotion stroop task were examined. We found greater posterior and medial cerebellar volume in the susceptible group tha

SUBMITTER: Wong NML 

PROVIDER: S-EPMC6875157 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature