Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial.

ABSTRACT:

Aim

Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes.

Methods

This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D₃ supplementation (50,000 IUs) or a matching comparator (5,000 IUs) for three months. The primary outcome was a battery of neuropsychological tests. Serum 25(OH)D was measured by liquid chromatography/tandem mass spectrometry. Repeated assessments of cognitive measures were collected over 12 weeks using alternative te

SUBMITTER: Byrn MA 

PROVIDER: S-EPMC6875298 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature