Transcriptome profiling analysis reveals key genes of different coat color in sheep skin.

ABSTRACT:

Background

To investigate the molecular mechanisms determining the coat color of native breed sheep in Xinjiang.

Methods

Bashibai sheep, Yemule white sheep and Tulufan black sheep were selected. Illumina HiSeq X Ten sequencing technology was used to detect the genes responsible for the white, light brown, black and cyan gray coat colors in sheep. Sequence analysis and functional gene annotation analysis were performed to analyze the results. The signal pathways and differentially expressed genes related to sheep hair color production regulation were screened and finally verified by real-time polymerase chain reaction.

Results

Functional annotation by Kyoto Encyclopedia of Genes and Genomes analysis revealed significant differences in enrichment of immunity-related pat

SUBMITTER: Yao L 

PROVIDER: S-EPMC6875393 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature