Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids.

ABSTRACT:

Purpose

Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in early life in an ovalbumin (OVA)-induced mouse model of AD.

Methods

The AD mouse model was developed by serial OVA sensitization and mice were treated with an antibiotic cocktail in their drinking water for 2 weeks before primary sensitization. Probiotics (Lactobacillus rhamnosus, 1 × 10⁹ CFU) or 100 μL of fresh fecal supernatant were orally administered daily from 1 week before the first sensitization until the end of the study.

Results

The AD mice which received antibiotics had significantly aggravated phenotypes, including clinical score, transepidermal water loss,

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC6875482 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature