Precision Oncology for Cancer Immunotherapies in Early-Phase Clinical Trials.

ABSTRACT: The clinical development of cancer drugs is rapidly moving from empirical "one drug fits all" or development-by-tumor-type approaches towards more personalized treatment models. A deeper understanding of cancer and the immune system, novel technologies, and powerful analytics have fueled an increase in precision oncology approaches integrating the molecular profiles of the tumor with the clinical profile of the patient. While this approach has been successful for targeted therapies, the complex mode of action of immunotherapies will likely require integration of clinical profiling with more comprehensive profiling of the tumor, of the tumor microenvironment, and of the immune system of the patient. Integration of precision oncology into clinical research for immunotherapies is viewed as a

SUBMITTER: Paliard X 

PROVIDER: S-EPMC6875515 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature