Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury.

ABSTRACT:

Objective

Emerging evidence suggests that injury to the anterior cruciate ligament (ACL) typically initiates biological changes that contribute to the development of osteoarthritis (OA). The molecular biomarkers or mediators of these biological events remain unknown. The goal of this exploratory study was to identify novel synovial fluid biomarkers associated with early biological changes following ACL injury distinct from findings in end-stage OA.

Methods

Synovial fluid was aspirated from patients with acute (≤30 days) and subacute (31-90 days) ACL tears and from patients with advanced OA and probed via tandem mass spectrometry for biomarkers to distinguish OA from ACL injury. Periostin (POSTN) was identified as a potential candidate. Further analyses of POSTN were performe

SUBMITTER: Brophy RH 

PROVIDER: S-EPMC6875635 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature