Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIM^SM.

ABSTRACT:

Background

This analysis describes the outcome for patients who received targeted therapy (TT) prior to or following high-dose interleukin-2 (HD IL-2).

Patients and methods

Patients with renal cell carcinoma (n = 352) receiving HD IL-2 were enrolled in Proleukin^R Observational Study to Evaluate the Treatment Patterns and Clinical Response in Malignancy (PROCLAIM^SM) beginning in 2011. Statistical analyses were performed using datasets as of September 24, 2015.

Results

Overall, there were 4% complete response (CR), 13% partial response (PR), 39% stable disease (SD), and 43% progressive disease (PD) with HD IL-2. The median overall survival (mOS) was not reached in patients with CR, PR, or SD, and was 15.5 months in patients with PD (median follow-u

SUBMITTER: Clark JI 

PROVIDER: S-EPMC6875755 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature