Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.

ABSTRACT: The activation of innate immune receptors by pathogen-associated molecular patterns (PAMPs) is central to host defense against infections. On the other hand, these receptors are also activated by immunogenic damage-associated molecular patterns (DAMPs), typically released from dying cells, and the activation can evoke chronic inflammatory or autoimmune disorders. One of the best known receptors involved in the immune pathogenesis is Toll-like receptor 7 (TLR7), which recognizes RNA with single-stranded structure. However, the causative DAMP RNA(s) in the pathogenesis has yet to be identified. Here, we first developed a chemical compound, termed KN69, that suppresses autoimmunity in several established mouse models. A subsequent search for KN69-binding partners led to the identification of

SUBMITTER: Negishi H 

PROVIDER: S-EPMC6876158 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature