Sildenafil improves exercise capacity in patients with cystic fibrosis: a proof-of-concept clinical trial.

ABSTRACT:

Background

Exercise intolerance is a common phenotype observed in patients with cystic fibrosis (CF). Treatment with sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has previously been shown to improve exercise capacity (VO₂ peak) in other patient populations. Thus, the present study sought to determine the acute and subacute effects of sildenafil on exercise capacity in patients with CF.

Methods

The present investigation utilized a randomized, double-blind, placebo-controlled, crossover study with an acute dose of either sildenafil (50 mg) or placebo (n = 13, age 25 ± 10), followed by a 4 week open-label extension with sildenafil (20 mg, TID; n = 15, age 23 ± 11). A comprehensive evaluation of pulmonary function and a maximal exercise test

SUBMITTER: Rodriguez-Miguelez P 

PROVIDER: S-EPMC6876159 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature