Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses.

ABSTRACT: The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses to commensal colonization are associated with the development of organized cellular clusters within the skin epithelium. These organized lymphocyte clusters are surrounded by keratinocytes expressing a discrete program associated with antigen presentation and antimicrobial defense. Notably, IL-22-mediated keratinocyte-intrinsic MHC class II expression was required for the selective accumulation of commensal-induced IFN-γ, but not IL-17A-producing CD4⁺ T cells within the skin. Taking these data together, this work uncovers an unexpec

SUBMITTER: Tamoutounour S 

PROVIDER: S-EPMC6876208 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature