Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome.

ABSTRACT:

Background

Major disparities between women and men in the diagnosis, management, and outcomes of acute coronary syndrome are well recognized.

Objectives

The aim of this study was to evaluate the impact of implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial infarction in women and men with suspected acute coronary syndrome.

Methods

Consecutive patients with suspected acute coronary syndrome were enrolled in a stepped-wedge, cluster-randomized controlled trial across 10 hospitals. Myocardial injury was defined as high-sensitivity cardiac troponin I concentration >99th centile of 16 ng/l in women and 34 ng/l in men. The primary outcome was recurrent myocardial infarction or cardiovascular death at 1 year.

Res

SUBMITTER: Lee KK 

PROVIDER: S-EPMC6876271 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature