Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study.

ABSTRACT:

Background

HIV infection is known to cause developmental delay, but the effects of HIV exposure without infection during pregnancy on child development are unclear. We compared the neurodevelopmental outcomes of HIV-exposed uninfected and HIV-unexposed children during their first 2 years of life.

Methods

Pregnant women (>18 years of age) at 20-28 weeks' gestation were enrolled into the Drakenstein Child Health cohort study while attending routine antenatal appointments at one of two peri-urban community-based clinics in Paarl, South Africa. Livebirths born to enrolled women during follow-up were included in the birth cohort. Mothers and infants received antenatal and postnatal HIV testing and antiretroviral therapy per local guidelines. Developmental assessments on the Bayle

SUBMITTER: Wedderburn CJ 

PROVIDER: S-EPMC6876655 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature