Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

ABSTRACT: Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in disease pathogenesis and enable the discovery of therapeutic targets, here we profile the transcriptomes of more than 100,000 single human cells, yielding molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver. We identify a scar-associated TREM2⁺CD9⁺ subpopulation of macrophages, which expands in liver fibrosis, differentiates from circulating monocytes and is pro-fibrogenic. We also define ACKR1⁺ and PLVAP⁺ endothelial cells that expand in cirrhosis,

SUBMITTER: Ramachandran P 

PROVIDER: S-EPMC6876711 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature