In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms.

ABSTRACT: Schistosomiasis is caused by a trematode of the genus Schistosoma and affects over 200 million people worldwide. The only drug recommended by the World Health Organization for treatment and control of schistosomiasis is praziquantel. Development of new drugs is therefore of great importance. Thiazoles are regarded as privileged structures with a broad spectrum of activities and are potential sources of new drug prototypes, since they can act through interactions with DNA and inhibition of DNA synthesis. In this context, we report the synthesis of a series of thiazole derivatives and their in vitro schistosomicidal activity by testing eight molecules (NJ03-08; NJ11-12) containing thiazole structures. Parameters such as motility and mortality, egg laying, pairing and parasite viability by AT

SUBMITTER: Pereira ASA 

PROVIDER: S-EPMC6876889 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature