Methamphetamine Users Show No Behavioral Deficits in Response Selection After Protracted Abstinence.

ABSTRACT: Introduction: Chronic recreational methamphetamine use causes dopaminergic neurotoxicity, which has been linked to impairments in executive functioning. Within this functional domain, response selection and the resolution of associated conflicts have repeatedly been demonstrated to be strongly modulated by dopamine. Yet, it has never been investigated whether chronic methamphetamine use leads to general impairments in response selection (i.e., irrespective of consumption-associated behavior) after substance use is discontinued. Materials and Methods: We tested n = 24 abstinent methamphetamine users (on average 2.7 years of abstinence) and n = 24 individually matched controls in a cross-sectional design with a flanker task. Results: Compared to healthy controls, former methamphetamine consu

SUBMITTER: Bensmann W 

PROVIDER: S-EPMC6877501 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature