Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.

ABSTRACT: There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10^-8), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10^-8) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10^-8), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10^-8). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX

SUBMITTER: Vijayakrishnan J 

PROVIDER: S-EPMC6877561 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature