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Hepatocyte gene expression and DNA methylation as ancestry-dependent mechanisms in African Americans.

ABSTRACT: African Americans (AAs) are an admixed population with widely varying proportion of West African ancestry (WAA). Here we report the correlation of WAA to gene expression and DNA methylation in AA-derived hepatocytes, a cell type important in disease and drug response. We perform mediation analysis to test whether methylation is a mediator of the effect of ancestry on expression. GTEx samples and a second cohort are used as validation. One hundred and thirty-one genes are associated with WAA (FDR?

SUBMITTER: Park CS 

PROVIDER: S-EPMC6877651 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Hepatocyte gene expression and DNA methylation as ancestry-dependent mechanisms in African Americans.

Park C S CS   De T T   Xu Y Y   Zhong Y Y   Smithberger E E   Alarcon C C   Gamazon E R ER   Perera M A MA  

NPJ genomic medicine 20191125

African Americans (AAs) are an admixed population with widely varying proportion of West African ancestry (WAA). Here we report the correlation of WAA to gene expression and DNA methylation in AA-derived hepatocytes, a cell type important in disease and drug response. We perform mediation analysis to test whether methylation is a mediator of the effect of ancestry on expression. GTEx samples and a second cohort are used as validation. One hundred and thirty-one genes are associated with WAA (FDR  ...[more]

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