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Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID).

ABSTRACT: Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherent reduced capacity or inablility to reject a graft have to be considered.

SUBMITTER: Haddad E 

PROVIDER: S-EPMC6877719 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Hematopoietic Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID).

Haddad Elie E   Hoenig Manfred M  

Frontiers in pediatrics 20191119

Severe Combined Immunodeficiencies (SCID) are a heterogeneous group of monogenetic diseases. We describe the typical clinical presentation of patients with SCID as well as basic principles in diagnosis and therapy by hematopoietic stem cell transplantation. Therapeutic strategies may differ between subtypes and the inherent reduced capacity or inablility to reject a graft have to be considered. ...[more]

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