Hsa_circ_0007841: A Novel Potential Biomarker and Drug Resistance for Multiple Myeloma.

ABSTRACT: Purpose: Circular RNA (circRNA) is a key regulatory factor in the development and progression of human tumors. However, the working mechanism and clinical significance of most circRNAs remain unknown in human cancers, including multiple myeloma (MM). Patients and Methods: This study employs high-throughput circRNA microarray with bioinformatics to identify differentially expressed circRNAs in patients with MM. The hsa_circ_0007841 expressions were observed in the MM tissues of 86 patients. Drug-resistant cell lines and pathological features were also detected. In addition, the relationship between hsa_circ_0007841 expressions in the MM tissues and the pathological features of patients with MM were evaluated and role of hsa_circ_0007841 as a potential biomarker and therapeutic

SUBMITTER: Gao M 

PROVIDER: S-EPMC6877741 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature