Discovery of early life stress interacting and sex-specific quantitative trait loci impacting cocaine responsiveness.

ABSTRACT:

Background and purpose

Addiction vulnerability involves complex gene X environment interactions leading to a pathological response to drugs. Identification of the genes involved in these interactions is an important step in understanding the underlying neurobiology and rarely have such analyses examined sex-specific influences. To dissect this interaction, we examined the impact of prenatal stress (PNS) on cocaine responsiveness in male and female mice of the BXD recombinant inbred panel.

Experimental approach

BXD strains were subjected to timed mating and assigned to PNS or control groups. PNS dams were subjected to restraint stress (1-hr restraint, three times daily) starting between embryonic day (E) 11 and 14 and continued until parturition. Adult male and female, contro

SUBMITTER: Bagley JR 

PROVIDER: S-EPMC6877791 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature