G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.

ABSTRACT: Asthma is a heterogeneous inflammatory disease of the airways that is associated with airway hyperresponsiveness and airflow limitation. Although asthma was once simply categorized as atopic or nonatopic, emerging analyses over the last few decades have revealed a variety of asthma endotypes that are attributed to numerous pathophysiological mechanisms. The classification of asthma by endotype is primarily routed in different profiles of airway inflammation that contribute to bronchoconstriction. Many asthma therapeutics target G protein-coupled receptors (GPCRs), which either enhance bronchodilation or prevent bronchoconstriction. Short-acting and long-acting β ₂-agonists are widely used bronchodilators that signal through the activation of the β ₂-adre

SUBMITTER: Wendell SG 

PROVIDER: S-EPMC6878000 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature