Association between fine mapping thymic stromal lymphopoietin and atopic dermatitis onset and persistence.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common chronic relapsing skin disease. Genetic variants have been associated with skin barrier function and immune regulation. Thymic stromal lymphopoietin (TSLP), an immune regulator, has been previously associated with AD.

Objective

To fine map TSLP and evaluate associations with the onset and persistence of AD.

Methods

TSLP variation was determined using targeted massively parallel sequencing in a longitudinal cohort of children with AD. Evaluations included linkage disequilibrium and the persistence of AD for as many as 10 years of follow-up. The association between the presence of AD and rs1898671 variation was evaluated in a second independent cohort.

Results

The minor variant frequency for rs1898671 was 23.5% (95% C

SUBMITTER: Lou C 

PROVIDER: S-EPMC6878172 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature