A guide on gene prioritization in studies of psychiatric disorders.

ABSTRACT: There has been an increasing interest in the identification of genetic variants causing individual differences in human behavior. Psychiatrists have contributed to the genetics field by defining the most important behavioral characteristics and by studying the association between genetic variants and behavioral differences within phenotypically well-characterized samples in which detailed assessments have been collected (e.g. neuroimaging). These samples are typically limited in size and are therefore not suitable for a genome-wide association analysis. Instead, gene association studies conducted in such samples typically focus on a few genes of interest, allowing smaller sample sizes. However, the selection of high-priority genes is not always straightforward and psychiatrists will usuall

SUBMITTER: Stringer S 

PROVIDER: S-EPMC6878611 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature