Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension.

ABSTRACT:

Background

Elevated intracranial pressure (ICP) is observed in association with a range of brain disorders. One of these challenging disorders is idiopathic intracranial hypertension (IIH), characterized by raised ICP of unknown cause with significant morbidity and limited therapeutic options. In this review, special focus is put on the preclinical research performed in order to understand the pathophysiology behind ICP regulation and IIH. This includes cerebrospinal fluid dynamics, molecular mechanisms underlying disturbances in brain fluids leading to elevated ICP, role of obesity in IIH, development of an IIH model and ICP measurements in rodents. The review also discusses existing and new drug targets for IIH that have been evaluated in vivo.

Conclusions

ICP monitoring i

SUBMITTER: Eftekhari S 

PROVIDER: S-EPMC6878629 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature