Use of a vibrating mesh nebulizer for allergen challenge.

ABSTRACT:

Background

Allergen inhalation tests are a valuable research tool. The allergen dose producing an early asthmatic response (EAR) can be predicted from methacholine responsiveness and allergen skin test endpoint (STE). The Wright^® jet nebulizer, which is both inefficient and increasingly difficult to obtain, has been used historically. We assessed the Solo^® vibrating mesh nebulizer as an alternative for allergen and methacholine challenges.

Methods

Eighteen mild atopic asthmatics completed the study. Doubling concentration allergen prick skin tests were performed to determine the STE in allergen units/mL. The Wright^® protocol was used to measure the methacholine provocation dose causing a 20% forced expired volume in one second (FEV₁

SUBMITTER: Cockcroft DW 

PROVIDER: S-EPMC6878640 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature