Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis.

ABSTRACT:

Background

Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21 loci, i.e. the two strongest CAD risk loci, with risk of AVS.

Methods

We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS. Cases and controls were stratified by CAD status. External validation of findings was undertaken in five cohorts including 7880 cases and 851,152 controls.

Results

In the meta-analysis including 4651 cases and 8231 controls the CAD-associ

SUBMITTER: Trenkwalder T 

PROVIDER: S-EPMC6878659 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature