Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods.

ABSTRACT: Scrapie in goats has been known since 1942, the archetype of prion diseases in which only prion protein (PrP) in misfolded state (PrP^Sc) acts as infectious agent with fatal consequence. Emergence of bovine spongiform encephalopathy (BSE) with its zoonotic behaviour and detection in goats enhanced fears that its source was located in small ruminants. However, in goats knowledge on prion strain typing is limited. A European-wide study is presented concerning the biochemical phenotypes of the protease resistant fraction of PrP^Sc (PrP^res) in over thirty brain isolates from transmissible spongiform encephalopathy (TSE) affected goats collected in seven countries. Three different scrapie forms were found: classical scrapie (CS), Nor98/atypical scrapie and one cas

SUBMITTER: Langeveld JPM 

PROVIDER: S-EPMC6878695 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature