S100P is a molecular determinant of E-cadherin function in gastric cancer.

ABSTRACT: BACKGROUND:E-cadherin has been awarded a key role in the aetiology of both sporadic and hereditary forms of gastric cancer. In this study, we aimed to identify molecular interactors that influence the expression and function of E-cadherin associated to cancer. METHODS:A data mining approach was used to predict stomach-specific candidate genes, uncovering S100P as a key candidate. The role of S100P was evaluated through in vitro functional assays and its expression was studied in a gastric cancer tissue microarray (TMA). RESULTS:S100P was found to contribute to a cancer pathway dependent on the context of E-cadherin function. In particular, we demonstrated that S100P acts as an E-cadherin positive regulator in a wild-type E-cadherin context, and its inhibition results in decreased E-cadheri

SUBMITTER: Carneiro P 

PROVIDER: S-EPMC6878717 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature