Mapping the Lineage Relationship between CXCR5⁺ and CXCR5^- CD4⁺ T Cells in HIV-Infected Human Lymph Nodes.

ABSTRACT: CXCR5 is a key marker of follicular helper T (T_FH) cells. Using primary lymph nodes (LNs) from HIV-infected patients, we identified a population of CXCR5^- CD4⁺ T cells with T_FH-cell-like features. This CXCR5^- subset becomes expanded in severe HIV infection and is characterized by the upregulation of activation markers and high PD-1 and ICOS surface expression. Integrated analyses on the phenotypic heterogeneity, functional capacity, T cell receptor (TCR) repertoire, transcriptional profile, and epigenetic state of CXCR5^-PD-1⁺ICOS⁺ T cells revealed a shared clonal relationship with T_FH cells. CXCR5^-PD-1⁺ICOS⁺ T cells retained a poised state for CXCR5 expression

SUBMITTER: Del Alcazar D 

PROVIDER: S-EPMC6878759 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature