Optimizing the Power to Identify the Genetic Basis of Complex Traits with Evolve and Resequence Studies.

ABSTRACT: Evolve and resequence (E&R) studies are frequently used to dissect the genetic basis of quantitative traits. By subjecting a population to truncating selection for several generations and estimating the allele frequency differences between selected and nonselected populations using next-generation sequencing (NGS), the loci contributing to the selected trait may be identified. The role of different parameters, such as, the population size or the number of replicate populations has been examined in previous works. However, the influence of the selection regime, that is the strength of truncating selection during the experiment, remains little explored. Using whole genome, individual based forward simulations of E&R studies, we found that the power to identify the causative alleles may be ma

SUBMITTER: Vlachos C 

PROVIDER: S-EPMC6878953 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature