The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans.

ABSTRACT:

Background and aim

When exceeding the homeostatic range, manganese (Mn) might cause neurotoxicity, characteristic of the pathophysiology of several neurological diseases. Although the underlying mechanism of its neurotoxicity remains unclear, Mn-induced oxidative stress contributes to disease etiology. DNA damage caused by oxidative stress may further trigger dysregulation of DNA-damage-induced poly(ADP-ribosyl)ation (PARylation), which is of central importance especially for neuronal homeostasis. Accordingly, this study was designed to assess in the genetically traceable in vivo model Caenorhabditis elegans the role of PARylation as well as the consequences of loss of pme-1 or pme-2 (orthologues of PARP1 and PARP2) in Mn-induced toxicity.

Methods

A specific and sensitive is

SUBMITTER: Neumann C 

PROVIDER: S-EPMC6878993 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature