Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus.

ABSTRACT:

Background

Status epilepticus (SE) is a prolonged and continuous seizure that lasts for at least 5 min. An episode of SE in a healthy system can lead to the development of spontaneous seizures and cognitive deficits which may be accompanied by hippocampal injury and microgliosis. Although the direct mechanisms underlying the SE-induced pathophysiology remain unknown, a candidate mechanism is hyperactivation of the classical complement pathway (C1q-C3 signaling). We recently reported that SE triggered an increase in C1q-C3 signaling in the hippocampus that closely paralleled cognitive decline. Thus, we hypothesized that blocking activation of the classical complement pathway immediately after SE may prevent the development of SE-induced hippocampal-dependent learning and memory defi

SUBMITTER: Schartz ND 

PROVIDER: S-EPMC6879103 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature