Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres.

ABSTRACT: Non-publication and publication bias in animal research is a core topic in current debates on the "reproducibility crisis" and "failure rates in clinical research". To date, however, we lack reliable evidence on the extent of non-publication in animal research. We collected a random and stratified sample (n = 210) from all archived animal study protocols of two major German UMCs (university medical centres) and tracked their results publication. The overall publication rate was 67%. Excluding doctoral theses as results publications, the publication rate decreased to 58%. We did not find substantial differences in publication rates with regard to i) the year of animal study approval, ii) the two UMCs, iii) the animal type (rodents vs. non-rodents), iv) the scope of research (basic vs. precl

SUBMITTER: Wieschowski S 

PROVIDER: S-EPMC6879110 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature