The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury.

ABSTRACT:

Background

In acute kidney injury (AKI), medication dosing based on Cockcroft-Gault creatinine clearance (CrCl) or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rates (eGFR) are not valid when serum creatinine (SCr) is not in steady state. The aim of this study was to determine the impact of a kinetic estimating equation that incorporates fluctuations in SCrs on drug dosing in critically ill patients.

Methods

We used data from participants enrolled in the NIH Acute Respiratory Distress Syndrome Network Fluid and Catheters Treatment Trial to simulate drug dosing category changes with the application of the kinetic estimating equation developed by Chen. We evaluated whether kinetic estimation of renal function would change medicati

SUBMITTER: Kwong YD 

PROVIDER: S-EPMC6879155 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature