Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome.

ABSTRACT:

Background

Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to define response to therapy and to identify if there is differential response in certain patients, i.e. existence of 'responders' and 'non responders' to therapy. This retrospective, observational study carried out in 2 tertiary referral paediatric intensive care units aims to characterize the change in Oxygen Saturation Index, following the administration of low dose methylprednisolone in a cohort of patients with PARDS, to identify what proportion of children treated demonstrated response, whether any particular characteristics predict response to t

SUBMITTER: Mitting RB 

PROVIDER: S-EPMC6879165 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature