Effect of MALAT1 Polymorphisms on Papillary Thyroid Cancer in a Chinese Population.

ABSTRACT: Background: Long noncoding RNA MALAT1 has been previously reported in the carcinogenesis of several tumors, and its potential functional polymorphisms have also been investigated in various diseases. However, the relationship between these polymorphisms and the susceptibility of thyroid cancer has still been largely unknown. In the present study, we aimed to explore the association between MALAT1 polymorphisms and thyroid cancer (TC) susceptibility, as well as potential biological function in TC. Methods: We conducted a case-control study with 1134 papillary thyroid cancer (PTC) patients and 1228 controls to evaluate the potential correlation between MALAT1 genetic variations (single nucleotide polymorphism, SNP) and the risk of PTC. More detailed molecular mechanisms were ex

SUBMITTER: Wen J 

PROVIDER: S-EPMC6879318 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature