NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation.

ABSTRACT: Naïve CD4⁺ T cells in the periphery differentiate into regulatory T cells (Tregs) in which Foxp3 is expressed for their suppressive function. NLRP3, a pro-inflammatory molecule, is known to be involved in inflammasome activation associated with several diseases. Recently, the expression of NLRP3 in CD4⁺ T cells, as well as in myeloid cells, has been described; however, a role of T cell-intrinsic NLRP3 in Treg differentiation remains unknown. Here, we report that NLRP3 impeded the expression of Foxp3 independent of inflammasome activation in Tregs. NLRP3-deficient mice elevate Treg generation in various organs in the de novo pathway. NLRP3 deficiency increased the amount and suppressive activity of Treg populations, whereas NLRP3 overexpression reduced Foxp3 exp

SUBMITTER: Park SH 

PROVIDER: S-EPMC6879348 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature