Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

ABSTRACT: INTRODUCTION:Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. OBJECTIVES:As the pathophysiological processes of pre-eclampsia are still uncertain, the present case-control study explored underlying metabolic processes characterising this disease. METHODS:Maternal peripheral plasma samples were collected from pre-eclamptic (n = 32) and healthy pregnant women (n = 35) in the third trimester. After extraction, high-resolution mass spectrometry-based untargeted metabolomics was used to profile polar and apolar metabolites and the resulting data were analysed via uni- and multivariate statistical approaches. RESULTS:The study demonstrated that the metabolome undergoes substantial changes in pre-eclamptic women. Amongst the most discriminativ

SUBMITTER: Sander KN 

PROVIDER: S-EPMC6879453 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature