Transcriptomic Analysis Links Eosinophilic Esophagitis and Atopic Dermatitis.

ABSTRACT: Background: Eosinophilic esophagitis (EoE) is commonly associated with concomitant atopic diseases including atopic dermatitis (AD) and allergic airway (AA) diseases including asthma. Despite this link and the shared pathologic features across these three disorders, detailed analyses of the unifying molecular pathways are lacking. Objectives: We sought to investigate the mRNA expression profile overlap between EoE, AA, and AD and to identify the involvement of interleukin 13 (IL-13) in modulating gene expression. Methods: Whole-genome mRNA expression analyses were performed on tissue specimens (biopsies or nasal brushes) from patients with EoE, AD, and AA, and IL-13-stimulated primary human epithelial cells from the esophagus, the skin, and the airways. Results:

SUBMITTER: Doucet-Ladeveze R 

PROVIDER: S-EPMC6879454 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature