Effect of imbalance in folate and vitamin B12 in maternal/parental diet on global methylation and regulatory miRNAs.

ABSTRACT: DNA methylation, a central component of the epigenetic network is altered in response to nutritional influences. In one-carbon cycle, folate acts as a one-carbon carrier and vitamin B12 acts as co-factor for the enzyme methionine synthase. Both folate and vitamin B12 are the important regulators of DNA methylation which play an important role in development in early life. Previous studies carried out in this regard have shown the individual effects of these vitamins but recently the focus has been to study the combined effects of both the vitamins during pregnancy. Therefore, this study was planned to elucidate the effect of the altered dietary ratio of folate and B12 on the expression of transporters, related miRNAs and DNA methylation in C57BL/6 mice. Female mice were fed diets with 9 co

SUBMITTER: Mahajan A 

PROVIDER: S-EPMC6879517 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature