Association of Extracellular Vesicle Protein Cargo with Race and Clinical Markers of Mortality.

ABSTRACT: Differential mortality rates remain a significant health disparity in the United States, suggesting the need to investigate novel potential molecular markers associated with mortality. Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, are lipid-bound vesicles secreted by cells into the circulation. EVs mediate intercellular communication by shuttling functional signaling molecules as cargo. EV characteristics by race in the context of mortality risk factors have not been described. We isolated plasma EVs from a cross-sectional cohort of African Americans (AA) and whites and found no significant differences in EV size, distribution or concentration between race or by sex. However, EV cargo showed increased levels of phospho-p53, total p53, cleaved caspase

SUBMITTER: Noren Hooten N 

PROVIDER: S-EPMC6879565 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature