Multimodal Cleavable Reporters for Quantifying Carboxy and Amino Groups on Organic and Inorganic Nanoparticles.

ABSTRACT: Organic and inorganic nanoparticles (NPs) are increasingly used as drug carriers, fluorescent sensors, and multimodal labels in the life and material sciences. These applications require knowledge of the chemical nature, total number of surface groups, and the number of groups accessible for subsequent coupling of e.g., antifouling ligands, targeting bioligands, or sensor molecules. To establish the concept of catch-and-release assays, cleavable probes were rationally designed from a quantitatively cleavable disulfide moiety and the optically detectable reporter 2-thiopyridone (2-TP). For quantifying surface groups on nanomaterials, first, a set of monodisperse carboxy-and amino-functionalized, 100 nm-sized polymer and silica NPs with different surface group densities was synthesized. Subs

SUBMITTER: Nirmalananthan-Budau N 

PROVIDER: S-EPMC6879591 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature