Short-term discontinuation of vagal nerve stimulation alters ¹⁸F-FDG blood pool activity: an exploratory interventional study in epilepsy patients.

ABSTRACT:

Background

Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by ¹⁸F-FDG uptake.

Results

Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after stimulation was switched off (VNS-off). In nine patients, ¹⁸F-FDG uptake was measured in the right carotid artery, aorta, bone marrow, spleen, and adipose tissue. Target-to-background ratios (TBRs) were calculated to normalize the respective standardized uptake values (SUVs) for venous blood pool activity. Median values are shown with interquartile range and compared using the Wilcoxon signed-rank test. Arterial SUVs tended to be higher during

SUBMITTER: Boswijk E 

PROVIDER: S-EPMC6879675 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature