Quantification of whole-brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T₂ -based oxygenation calibrations.

ABSTRACT:

Purpose

To evaluate different T₂ -oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA).

Methods

Blood T₂ values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T₂ -oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T₂ values to venous oxygenation, whole-brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated.

Results

Sickle blood samples' oxygenation values calculated from our individual calibrations agreed

SUBMITTER: Li W 

PROVIDER: S-EPMC6879787 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature